Title : Effect of 5-aminolevulinic acid on erythropoiesis: a preclinical in vitro characterization for the treatment of congenital sideroblastic anemia.

Pub. Date : 2014 Nov 7

PMID : 25450364






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 ALAS2 is a mitochondrial enzyme, which utilizes glycine and succinyl-CoA to form 5-aminolevulinic acid (ALA), a crucial precursor in heme synthesis. 5-amino levulinic acid 5'-aminolevulinate synthase 2 Homo sapiens
2 Therefore, ALA supplementation could be an effective therapeutic strategy to restore heme synthesis in CSA caused by ALAS2 defects. 5-amino levulinic acid 5'-aminolevulinate synthase 2 Homo sapiens
3 ALA may represent a novel therapeutic option for CSA treatment, particularly for cases harboring ALAS2 mutations. 5-amino levulinic acid 5'-aminolevulinate synthase 2 Homo sapiens