Title : Novel Hsp90 inhibitor FW-04-806 displays potent antitumor effects in HER2-positive breast cancer cells as a single agent or in combination with lapatinib.

Pub. Date : 2015 Jan 28

PMID : 25449780






1 Functional Relationships(s)
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1 We found that FW-04-806 alone or with laptinib inhibits cell proliferation, induces cell apoptosis and reduces the total and activated HER3 levels in these cells, while lapatinib has been reported to increase HER3 expression followed HER2 inhibition. Lapatinib erb-b2 receptor tyrosine kinase 3 Homo sapiens