Title : Characterization of the oxidant generation by inflammatory cells lavaged from rat lungs following acute exposure to ozone.

Pub. Date : 1989 Jun 15

PMID : 2544040






3 Functional Relationships(s)
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1 In contrast, luminol-amplified chemiluminescence increased 24 hr following ozone exposure, coinciding with an increase in the percentage of neutrophils and myeloperoxidase in the inflammatory cell population. Luminol myeloperoxidase Rattus norvegicus
2 Supporting the involvement of myeloperoxidase in the enhanced oxidant-generating status of these cells, the luminol-amplified chemiluminescence was found to be azide-, but not superoxide dismutase-inhibitable. Luminol myeloperoxidase Rattus norvegicus
3 Addition of myeloperoxidase to control alveolar macrophages resulted in enhanced luminol-amplified chemiluminescence, taurine chloramine generation, and enhanced chemiluminescence from benzo[a]pyrene-7,8-dihydrodiol demonstrating that, in the presence of myeloperoxidase, alveolar macrophages are capable of supporting myeloperoxidase-dependent reactions. Luminol myeloperoxidase Rattus norvegicus