Title : Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling.

Pub. Date : 2014 Nov 4

PMID : 25440058






1 Functional Relationships(s)
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1 Diminished sulfation of heparan sulfate resulted in enhanced chemokine expression; increased macrophages in plaques; increased expression of ACAT2, a key enzyme in cholesterol ester storage; and increased foam cell conversion. Heparitin Sulfate acetyl-Coenzyme A acetyltransferase 2 Mus musculus