Title : Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis.

Pub. Date : 2015 Feb

PMID : 25434487






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Continuous infusion of LY379268 also enhanced the expression of the glutamate transporter GLT-1, in the spinal cord. LY 379268 solute carrier family 1 (glial high affinity glutamate transporter), member 2 Mus musculus
2 At day 40 of treatment, LY379268 enhanced spinal cord levels of GDNF and GLT-1, and rescued spinal cord motor neurons, as assessed by stereologic counting of SMI-32(+) cells. LY 379268 solute carrier family 1 (glial high affinity glutamate transporter), member 2 Mus musculus