Title : Interleukin 1 and cyclic AMP induce kappa immunoglobulin light-chain expression via activation of an NF-kappa B-like DNA-binding protein.

Pub. Date : 1989 Mar

PMID : 2542770






5 Functional Relationships(s)
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1 In the present study, we found that these effects of IL-1 are mimicked by cyclic AMP (cAMP) analogs and cAMP-elevating drugs. Cyclic AMP interleukin 1 complex Mus musculus
2 In the present study, we found that these effects of IL-1 are mimicked by cyclic AMP (cAMP) analogs and cAMP-elevating drugs. Cyclic AMP interleukin 1 complex Mus musculus
3 In the present study, we found that these effects of IL-1 are mimicked by cyclic AMP (cAMP) analogs and cAMP-elevating drugs. Cyclic AMP interleukin 1 complex Mus musculus
4 The induction of kappa immunoglobulin light-chain gene expression by IL-1 was associated with an increase in intracellular cAMP levels. Cyclic AMP interleukin 1 complex Mus musculus
5 These results suggest that cAMP may play an important role as a second messenger for IL-1 in the induction of kappa immunoglobulin light-chain synthesis in pre-B cells via the activation of a DNA-binding protein that is similar or identical to NF-kappa B. Cyclic AMP interleukin 1 complex Mus musculus