Title : Capsaicin, nonivamide and trans-pellitorine decrease free fatty acid uptake without TRPV1 activation and increase acetyl-coenzyme A synthetase activity in Caco-2 cells.

Pub. Date : 2015 Jan

PMID : 25422952






3 Functional Relationships(s)
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1 Capsaicin and nonivamide were found to reduce fatty acid uptake, with IC50 values of 0.49 muM and 1.08 muM, respectively. Capsaicin latexin Homo sapiens
2 Capsaicin and nonivamide were found to reduce fatty acid uptake, with IC50 values of 0.49 muM and 1.08 muM, respectively. Capsaicin latexin Homo sapiens
3 However, acetyl-coenzyme A synthetase activity increased (p<0.05) in the presence of 10 muM capsaicin, nonivamide or trans-pellitorine, pointing to an increased fatty acid biosynthesis that might counteract the decreased fatty acid uptake. Capsaicin latexin Homo sapiens