Pub. Date : 2014 Dec 9
PMID : 25407882
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Baohuoside I suppresses invasion of cervical and breast cancer cells through the downregulation of CXCR4 chemokine receptor expression. | baohuoside I | C-X-C motif chemokine receptor 4 | Homo sapiens |
| 2 | In this report, we investigate baohuoside I, a component of Epimedium koreanum, as a regulator of CXCR4 expression as well as function in cervical cancer and breast cancer cells. | baohuoside I | C-X-C motif chemokine receptor 4 | Homo sapiens |
| 3 | We observed that baohuoside I downregulated CXCR4 expression in a dose- and time-dependent manner in HeLa cells. | baohuoside I | C-X-C motif chemokine receptor 4 | Homo sapiens |
| 4 | The decrease in the level of CXCR4 expression caused by baohuoside I was correlated with inhibition of the CXCL12-induced invasion of both cervical and breast cancer cells. | baohuoside I | C-X-C motif chemokine receptor 4 | Homo sapiens |
| 5 | Overall, our results show that baohuoside I exerts its antimetastatic effect through the downregulation of CXCR4 expression and, thus, has the potential to play a role in the suppression of cancer metastasis. | baohuoside I | C-X-C motif chemokine receptor 4 | Homo sapiens |