Title : Regulation of Macrophage Polarization by RON Receptor Tyrosine Kinase Signaling.

Pub. Date : 2014

PMID : 25400637






1 Functional Relationships(s)
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1 In this perspective, I discuss the function of recepteur d"origine nantais (RON) receptor tyrosine kinase in regulating the M2-like state of macrophage activation Besides decreasing pro-inflammatory cytokine production in response to toll-like receptor-4 activation, macrophage-stimulating protein strongly suppresses nitric oxide synthase and at the same time upregulates arginase, which is the rate limiting enzyme in the ornithine biosynthesis pathway. Ornithine toll like receptor 4 Homo sapiens