Title : Antiproliferative Effect of Lapatinib in HER2-Positive and HER2-Negative/HER3-High Breast Cancer: Results of the Presurgical Randomized MAPLE Trial (CRUK E/06/039).

Pub. Date : 2015 Jul 1

PMID : 25398453






2 Functional Relationships(s)
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1 CONCLUSIONS: Lapatinib has antiproliferative effects in a subgroup of HER2(-) nonamplified tumors characterized by high HER3 expression. Lapatinib erb-b2 receptor tyrosine kinase 3 Homo sapiens
2 The possible role of high HER2:HER3 heterodimers in predicting response to lapatinib merits investigation in HER2(-) tumors. Lapatinib erb-b2 receptor tyrosine kinase 3 Homo sapiens