Title : Influence of atrial natriuretic factor on 5-(N-ethyl-N-isopropyl)amiloride-sensitive 22Na+ uptake in rabbit aorta.

Pub. Date : 1989 Mar

PMID : 2539468






3 Functional Relationships(s)
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1 Because atrial natriuretic factor (Atriopeptin II, ANF) exerts potent effects on Na+ transport in a number of tissues, we examined its influence on 22Na+-uptake in isolated rabbit aorta segments and the possible relation to ANF-induced vasorelaxation. Sodium-22 natriuretic peptides A Oryctolagus cuniculus
2 ANF increased 22Na+-uptake by 44% with an EC50 of 12 nM whereas sodium nitroprusside was without effect. Sodium-22 natriuretic peptides A Oryctolagus cuniculus
3 These results suggest that ANF activation of EIPA-sensitive 22Na+-uptake occurs before cGMP formation perhaps at the level of the ANF receptor itself. Sodium-22 natriuretic peptides A Oryctolagus cuniculus