Pub. Date : 2014 Dec 1
PMID : 25385465
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A spectroscopic investigation of the complexes formed between the Pb(II) ion and D-penicillamine (H2Pen), a chelating agent used in the treatment of lead poisoning, was carried out on two sets of alkaline aqueous solutions with CPb(II) 10 and 100 mM, varying the H2Pen/Pb(II) molar ratio (2.0, 3.0, 4.0, 10.0). | Penicillamine | proprotein convertase subtilisin/kexin type 1 inhibitor | Homo sapiens |
| 2 | The combined spectroscopic results, reporting delta((207)Pb) 1870 ppm and lambdamax 298 nm for a Pb(II)S2NO site, are consistent with a dominating 1:2 lead(II):penicillamine complex with [Pb(S,N,O-Pen)(S-HnPen)](2-n) (n = 0-1) coordination in alkaline solutions, and provide useful structural information on how penicillamine can function as an antidote against lead toxicity in vivo. | Penicillamine | proprotein convertase subtilisin/kexin type 1 inhibitor | Homo sapiens |