Pub. Date : 2015 Feb
PMID : 25385265
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TP53 oncomorphic mutations predict resistance to platinum- and taxane-based standard chemotherapy in patients diagnosed with advanced serous ovarian carcinoma. | Platinum | tumor protein p53 | Homo sapiens |
| 2 | Patients with oncomorphic TP53 mutations demonstrated significantly worse PFS, a 60% higher risk of recurrence (HR=1.60, 95% confidence intervals 1.09, 2.33, p=0.015), and higher rates of platinum resistance (chi(2) test p=0.0024) when compared with single nucleotide mutations not categorized as oncomorphic. | Platinum | tumor protein p53 | Homo sapiens |