Title : Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm.

Pub. Date : 2015 Jan

PMID : 25378412






1 Functional Relationships(s)
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1 In vitro experiments revealed that angiotensin II stimulated the NLRP3 inflammasome activation and subsequent interleukin-1beta release in macrophages, and this activation was mediated through an angiotensin type I receptor/mitochondria-derived reactive oxygen species-dependent pathway. Reactive Oxygen Species interleukin 1 beta Mus musculus