Title : Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer's disease.

Pub. Date : 2014 Nov 5

PMID : 25378159






2 Functional Relationships(s)
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1 We showed previously that inhibition of monoacylglycerol lipase (MAGL), the primary enzyme that metabolizes the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain, robustly reduces Abeta by inhibiting beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), a key enzyme responsible for Abeta formation. Endocannabinoids beta-site APP cleaving enzyme 1 Mus musculus
2 We showed previously that inhibition of monoacylglycerol lipase (MAGL), the primary enzyme that metabolizes the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain, robustly reduces Abeta by inhibiting beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), a key enzyme responsible for Abeta formation. Endocannabinoids beta-site APP cleaving enzyme 1 Mus musculus