Title : A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4.

Pub. Date : 2014 Nov 6

PMID : 25375376






1 Functional Relationships(s)
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1 We conclude that a downregulation of mitochondrial ETC generally induces adaptive pro-survival responses, which are specifically abrogated by the suicidal p53 response triggered by the genetic risks of the pyrimidine nucleotide deficiency. Pyrimidine Nucleotides tumor protein p53 Homo sapiens