Title : A functional approach reveals a genetic and physical interaction between ribonucleotide reductase and CHK1 in mammalian cells.

Pub. Date : 2014

PMID : 25375241






1 Functional Relationships(s)
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Protein Name
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1 Combinatorial ablation of RRM1 or RRM2 and Chk1 causes a dramatic accumulation of gamma-H2AX, a marker of double-strand DNA breaks, suggesting that activation of Chk1 in this context is essential for suppression of DNA damage. gamma-h2ax ribonucleotide reductase catalytic subunit M1 Homo sapiens