Title : MTOR inhibition enhances NVP-AUY922-induced autophagy-mediated KIT degradation and cytotoxicity in imatinib-resistant gastrointestinal stromal tumors.

Pub. Date : 2014 Nov 30

PMID : 25375091






1 Functional Relationships(s)
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1 The combination of low-dose NVP-AUY922 with rapamycin had comparable effects on reducing KIT expression, increasing MAP1LC3B puncta and tumor necrosis, and inhibiting tumor growth as high-dose NVP-AUY922 did in GIST430 xenograft model. Sirolimus microtubule associated protein 1 light chain 3 beta Homo sapiens