Pub. Date : 2015 Apr
PMID : 25371038
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that the non-receptor tyrosine kinase Src mediates TACE activation in mechanically stretched rat cardiomyocytes by phosphorylating the Tyr-702 residue within the intracellular tail of TACE. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 2 | The rapid activation of Src in mechanically stretched cardiomyocytes is followed by TACE phosphorylation on Tyr-702, leading to activation of p38 MAPK, a kinase that is an effector of TNFalpha receptor activation. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 3 | Pharmacological inhibition or silencing of Src attenuated stretch-induced TACE phosphorylation on Tyr-702 and p38 activation. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |