Title : Increased gene delivery efficiency and specificity of a lipid-based nanosystem incorporating a glycolipid.

Pub. Date : 2014

PMID : 25368518






3 Functional Relationships(s)
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1 In the presence of galactose, which competes with lactosyl-PE for the binding to the asialoglycoprotein receptor (ASGP-R), a significant reduction in biological activity was observed, showing that the potentiation of transfection induced by the presence of lactosyl-PE could be due to its specific interaction with ASGP-R, which is overexpressed in HCC. Galactose asialoglycoprotein receptor 1 Homo sapiens
2 In the presence of galactose, which competes with lactosyl-PE for the binding to the asialoglycoprotein receptor (ASGP-R), a significant reduction in biological activity was observed, showing that the potentiation of transfection induced by the presence of lactosyl-PE could be due to its specific interaction with ASGP-R, which is overexpressed in HCC. Galactose asialoglycoprotein receptor 1 Homo sapiens
3 In the presence of galactose, which competes with lactosyl-PE for the binding to the asialoglycoprotein receptor (ASGP-R), a significant reduction in biological activity was observed, showing that the potentiation of transfection induced by the presence of lactosyl-PE could be due to its specific interaction with ASGP-R, which is overexpressed in HCC. Galactose asialoglycoprotein receptor 1 Homo sapiens