Title : Inhibition of heat shock protein 27 phosphorylation promotes sensitivity to 5-fluorouracil in colorectal cancer cells.

Pub. Date : 2014 Dec

PMID : 25364415






1 Functional Relationships(s)
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1 Treatment with a selective inhibitor, p38 mitogen-activated protein kinase (MAPK; SB203580), caused the dose-dependent suppression of HSP27 phosphorylation, which was upregulated by 5-FU, reducing the half maximal inhibitory concentration values of 5-FU in the HCT116 and HCT15 cells. SB 203580 heat shock protein family B (small) member 1 Homo sapiens