Title : Demethyleneberberine, a natural mitochondria-targeted antioxidant, inhibits mitochondrial dysfunction, oxidative stress, and steatosis in alcoholic liver disease mouse model.

Pub. Date : 2015 Jan

PMID : 25362106






1 Functional Relationships(s)
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1 Moreover, we also found that DMB suppressed CYP2E1, hypoxia inducible factor alpha, and inducible nitric oxide synthase, which contributed to oxidative stress and restored sirtuin 1/AMP-activated protein kinase/peroxisome proliferator-activated receptor-gamma coactivator-1alpha pathway-associated fatty acid oxidation in chronic ethanol-fed mice, which in turn ameliorated lipid peroxidation and macrosteatosis in the liver. demethyleneberberine nitric oxide synthase 2, inducible Mus musculus