Title : Gefitinib loaded folate decorated bovine serum albumin conjugated carboxymethyl-beta-cyclodextrin nanoparticles enhance drug delivery and attenuate autophagy in folate receptor-positive cancer cells.

Pub. Date : 2014 Oct 30

PMID : 25358257






3 Functional Relationships(s)
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1 Gefitinib loaded folate decorated bovine serum albumin conjugated carboxymethyl-beta-cyclodextrin nanoparticles enhance drug delivery and attenuate autophagy in folate receptor-positive cancer cells. Folic Acid albumin Homo sapiens
2 In order to utilize FA-FR binding specificity to achieve targeted delivery of drugs into tumor cells, we prepared Gefitinib loaded folate decorated bovine serum albumin conjugated carboxymethyl-beta-cyclodextrin nanoparticles for enhancing drug delivery in cancer cells. Folic Acid albumin Homo sapiens
3 RESULTS: We prepared folic acid (FA)-decorated bovine serum albumin (BSA) conjugated carboxymethyl-beta-cyclodextrin (CM-beta-CD) nanoparticles (FA-BSA-CM-beta-CD NPs) capable of entrapping a hydrophobic Gefitinib. Folic Acid albumin Homo sapiens