Pub. Date : 2015 Jan 15
PMID : 25348516
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We tested the top hit in the screen, the MEK1/2 inhibitor, AZD6244, for efficacy alone or in combination with the PI3K inhibitors, BKM120 or GDC-0941, in a Kras(G12D)-driven GEMM that recapitulates the histopathogenesis of human PDAC. | AZD 6244 | mitogen-activated protein kinase kinase 1 | Homo sapiens |
| 2 | The response profile to the MEK1/2 inhibitor, AZD6244, was an outlier, showing the highest selective efficacy in PDAC. | AZD 6244 | mitogen-activated protein kinase kinase 1 | Homo sapiens |