Title : Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2.

Pub. Date : 2014 Dec

PMID : 25339683






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Preincubation of vesicles containing SM with acid sphingomyelinase (ASM) (SM phosphodiesterase, EC 3.1.4.12) results in hydrolysis of SM to ceramide (Cer), which enhances cholesterol transfer. Samarium sphingomyelin phosphodiesterase 1 Homo sapiens
2 Preincubation of vesicles containing SM with acid sphingomyelinase (ASM) (SM phosphodiesterase, EC 3.1.4.12) results in hydrolysis of SM to ceramide (Cer), which enhances cholesterol transfer. Samarium sphingomyelin phosphodiesterase 1 Homo sapiens
3 Preincubation of vesicles containing SM with acid sphingomyelinase (ASM) (SM phosphodiesterase, EC 3.1.4.12) results in hydrolysis of SM to ceramide (Cer), which enhances cholesterol transfer. Samarium sphingomyelin phosphodiesterase 1 Homo sapiens
4 Anionic phospholipids derived from the plasma membrane (phosphatidylglycerol and phosphatidic acid) stimulate SM and phosphatidylcholine hydrolysis by ASM more effectively than BMP, which is generated during endocytosis. Samarium sphingomyelin phosphodiesterase 1 Homo sapiens