Title : Genetic variations associated with the effect of testicular cancer treatment on gonadal hormones.

Pub. Date : 2014 Dec

PMID : 25336703






2 Functional Relationships(s)
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1 SUMMARY ANSWER: Variations in LH receptor (LHR) and in 5alpha-reductase II (SRD5A2) genes may modify the effect of TC treatment on testosterone levels, whereas genetic variations in the androgen receptor (AR) may modify the effect on LH levels. Testosterone steroid 5 alpha-reductase 2 Homo sapiens
2 For SRD5A2 A49T, testosterone levels were lower after radiotherapy compared with after surgery, but only for the heterozygotes for the polymorphism (39% lower, P = 0.001). Testosterone steroid 5 alpha-reductase 2 Homo sapiens