Title : Let-7b binding site polymorphism in the B-cell lymphoma-extra large 3'UTR is associated with fluorouracil resistance of hepatocellular carcinoma.

Pub. Date : 2015 Jan

PMID : 25333670






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Overexpression of the Bcl-xl mutated (C) allele in BEL-7402 HCC cells significantly decreased fluorouracil (5-FU) sensitivity, as compared with mock transfection and overexpression of the wild-type allele. Fluorouracil BCL2 like 1 Homo sapiens
2 Overexpression of the Bcl-xl mutated (C) allele in BEL-7402 HCC cells significantly decreased fluorouracil (5-FU) sensitivity, as compared with mock transfection and overexpression of the wild-type allele. Fluorouracil BCL2 like 1 Homo sapiens
3 From this, it was concluded that let-7b increased 5-FU sensitivity by repressing Bcl-xl expression in HCC cells. Fluorouracil BCL2 like 1 Homo sapiens