Title : Different influences of extracellular and intracellular superoxide on relaxation through the NO/sGC/cGMP pathway in isolated rat iliac arteries.

Pub. Date : 2015 Feb

PMID : 25329747






4 Functional Relationships(s)
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1 Different influences of extracellular and intracellular superoxide on relaxation through the NO/sGC/cGMP pathway in isolated rat iliac arteries. Superoxides guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus
2 Superoxide production is increased in diseased blood vessels, which is considered to lead to impairment of the nitric oxide (NO)/soluble guanylate cyclase (sGC)/cGMP pathway. Superoxides guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus
3 These findings suggest that extracellular superoxide reacts with NO only outside the cell, whereas intracellular superoxide not only scavenges NO inside the cell but also shifts the sGC redox equilibrium. Superoxides guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus
4 These findings suggest that extracellular superoxide reacts with NO only outside the cell, whereas intracellular superoxide not only scavenges NO inside the cell but also shifts the sGC redox equilibrium. Superoxides guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus