Pub. Date : 2014 Dec
PMID : 25329094
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We hypothesized that isoflurane, sevoflurane, and desflurane would exert variable degrees of neurotoxicity in vitro and in vivo via activation of the p75 neurotrophin receptor (p75). | Isoflurane | PC4 and SFRS1 interacting protein 1 | Homo sapiens |
| 2 | We hypothesized that isoflurane, sevoflurane, and desflurane would exert variable degrees of neurotoxicity in vitro and in vivo via activation of the p75 neurotrophin receptor (p75). | Isoflurane | PC4 and SFRS1 interacting protein 1 | Homo sapiens |
| 3 | Pharmacological inhibition or siRNA knockdown of p75 counteracted the aggravating effects of isoflurane. | Isoflurane | PC4 and SFRS1 interacting protein 1 | Homo sapiens |
| 4 | Isoflurane increased RGC damage in vivo (IRI 1479 RGC/mm(2) [1311/1697] versus IRI + isoflurane 1170 [1093/1211], P = 0.03), which was counteracted by p75-inhibition via TAT-pep5 (P = 0.02). | Isoflurane | PC4 and SFRS1 interacting protein 1 | Homo sapiens |
| 5 | CONCLUSIONS: Isoflurane but not sevoflurane or desflurane postexposure aggravates neurotoxicity in preinjured neurons via activation of p75 and NF-kappaB. | Isoflurane | PC4 and SFRS1 interacting protein 1 | Homo sapiens |