Pub. Date : 2015 Jan
PMID : 25318994
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Among them, bupropion and nifedipine showed high selectivity to CYP2C76. | Nifedipine | cytochrome P450 family 2 subfamily C member 76 | Macaca fascicularis |
| 2 | As for nifedipine, CYP2C76 formed methylhydroxylated nifedipine, which was not produced by monkey CYP2C9, CYP2C19, or CYP3A4, as identified by mass spectrometry and estimated by a molecular docking simulation. | Nifedipine | cytochrome P450 family 2 subfamily C member 76 | Macaca fascicularis |
| 3 | As for nifedipine, CYP2C76 formed methylhydroxylated nifedipine, which was not produced by monkey CYP2C9, CYP2C19, or CYP3A4, as identified by mass spectrometry and estimated by a molecular docking simulation. | Nifedipine | cytochrome P450 family 2 subfamily C member 76 | Macaca fascicularis |
| 4 | This unique oxidative metabolite formation of nifedipine could be one of the selective marker reactions of CYP2C76 among the major CYP2Cs and CYP3As tested. | Nifedipine | cytochrome P450 family 2 subfamily C member 76 | Macaca fascicularis |
| 5 | These results suggest that monkey CYP2C76 contributes to bupropion hydroxylation and formation of different nifedipine oxidative metabolites as a result of its relatively large substrate cavity. | Nifedipine | cytochrome P450 family 2 subfamily C member 76 | Macaca fascicularis |