Title : Inhibition of autophagy by chloroquine potentiates synergistically anti-cancer property of artemisinin by promoting ROS dependent apoptosis.

Pub. Date : 2014 Dec

PMID : 25308836






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Inhibition of autophagy by CQ pre-treatment led to accumulation of acidic vacuoles (AVOs) which acquainted with unprocessed damage mitochondria that subsequently promoted ROS generation, and resulted releases of Cyt C in cytosol that caused caspase-3 dependent apoptosis cell death in ART-treated A549 cells. Chloroquine caspase 3 Homo sapiens