Pub. Date : 2015 Nov
PMID : 25307283
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses. | sulforaphane | histone deacetylase 9 | Homo sapiens |
| 2 | Sulforaphane is a natural product found in broccoli, which is known to exert many different molecular effects in the cell, including inhibition of histone deacetylase (HDAC) enzymes. | sulforaphane | histone deacetylase 9 | Homo sapiens |
| 3 | Sulforaphane is a natural product found in broccoli, which is known to exert many different molecular effects in the cell, including inhibition of histone deacetylase (HDAC) enzymes. | sulforaphane | histone deacetylase 9 | Homo sapiens |
| 4 | Significant inhibition of HDAC activity in HCT116 nuclear extracts required prolonged exposure to sulforaphane in the presence of serum. | sulforaphane | histone deacetylase 9 | Homo sapiens |
| 5 | Both cell types displayed down-regulation of HDAC protein levels by sulforaphane treatment. | sulforaphane | histone deacetylase 9 | Homo sapiens |
| 6 | Despite these reductions in HDAC family member protein levels, acetylation of marker proteins (acetylated Histone H3, H4, and tubulin) was decreased by sulforaphane treatment. | sulforaphane | histone deacetylase 9 | Homo sapiens |
| 7 | In addition, our data suggest that keratinocytes are at least partially resistant to the nuclear HDAC inhibitory effects of sulforaphane, which is exhibited in HCT116 and other cells. | sulforaphane | histone deacetylase 9 | Homo sapiens |