Title : Metformin displays anti-myeloma activity and synergistic effect with dexamethasone in in vitro and in vivo xenograft models.

Pub. Date : 2015 Jan 28

PMID : 25305450






2 Functional Relationships(s)
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Protein Name
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1 IGF-I blocked metformin-induced MM cell apoptosis and reactivation of the PI3K/AKT/mTOR signaling pathway. Metformin AKT serine/threonine kinase 1 Homo sapiens
2 We conclude that metformin inhibits MM cell proliferation through the IGF-1R/PI3K/AKT/mTOR signaling pathway. Metformin AKT serine/threonine kinase 1 Homo sapiens