Pub. Date : 2014 Nov 21
PMID : 25294879
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Connexin 46 (cx46) gap junctions provide a pathway for the delivery of glutathione to the lens nucleus. | Glutathione | gap junction protein, alpha 3 | Mus musculus |
| 2 | Connexin 46 (cx46) gap junctions provide a pathway for the delivery of glutathione to the lens nucleus. | Glutathione | gap junction protein, alpha 3 | Mus musculus |
| 3 | Single channel permeation of the larger GSH anion was low but detectable (P(Na)/P(GSH) ~12 for Cx46 and ~8 for Cx50), whereas permeation of divalent anion glutathione disulfide (GSSG) was undetectable. | Glutathione | gap junction protein, alpha 3 | Mus musculus |
| 4 | Single channel permeation of the larger GSH anion was low but detectable (P(Na)/P(GSH) ~12 for Cx46 and ~8 for Cx50), whereas permeation of divalent anion glutathione disulfide (GSSG) was undetectable. | Glutathione | gap junction protein, alpha 3 | Mus musculus |
| 5 | Measurement of GSH levels in the lenses from connexin knock-out (KO) mice indicated Cx46, and not Cx50, is necessary for transport of GSH to the core. | Glutathione | gap junction protein, alpha 3 | Mus musculus |
| 6 | Levels of GSH in the nucleus were markedly reduced in Cx46 KO, whereas they were unaffected by Cx50 KO. | Glutathione | gap junction protein, alpha 3 | Mus musculus |
| 7 | These results indicate that glutathione diffuses from cortical fiber cells to the nucleus via gap junction channels formed by Cx46. | Glutathione | gap junction protein, alpha 3 | Mus musculus |