Title : Substrate specificity of human protein arginine methyltransferase 7 (PRMT7): the importance of acidic residues in the double E loop.

Pub. Date : 2014 Nov 21

PMID : 25294873






1 Functional Relationships(s)
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1 After confirming its type III activity generating only omega-N(G)-monomethylarginine and its distinct substrate specificity for RXR motifs surrounded by basic residues, we performed site-directed mutagenesis studies on this enzyme, revealing that two acidic residues within the double E loop, Asp-147 and Glu-149, modulate the substrate preference. Aspartic Acid retinoid X receptor alpha Homo sapiens