Title : Decreasing GSH and increasing ROS in chemosensitivity gliomas with IDH1 mutation.

Pub. Date : 2015 Feb

PMID : 25283382






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Decreasing GSH and increasing ROS in chemosensitivity gliomas with IDH1 mutation. Glutathione isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 The IDH1-R132H-induced higher chemosensitivity was associated with nicotine adenine disphosphonucleotide (NADPH), glutathione (GSH) depletion, and reactive oxygen species (ROS) generation. Glutathione isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
3 The IDH1-R132H-induced higher chemosensitivity was associated with nicotine adenine disphosphonucleotide (NADPH), glutathione (GSH) depletion, and reactive oxygen species (ROS) generation. Glutathione isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
4 Accordingly, this IDH1-R132H-induced growth inhibition was effectively abrogated by GSH in vitro and in vivo. Glutathione isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens