Title : Somatic copy number alterations predict response to platinum therapy in epithelial ovarian cancer.

Pub. Date : 2014 Dec

PMID : 25281495






2 Functional Relationships(s)
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1 CONCLUSIONS: We established that amplifications in 14q32.33 were associated with reduced OS, PFS, PFI and platinum resistance in three independent cohorts, suggesting that AKT1 amplifications act as a potentially predictive marker for EOC treated with platinum-based chemotherapy. Platinum AKT serine/threonine kinase 1 Homo sapiens
2 CONCLUSIONS: We established that amplifications in 14q32.33 were associated with reduced OS, PFS, PFI and platinum resistance in three independent cohorts, suggesting that AKT1 amplifications act as a potentially predictive marker for EOC treated with platinum-based chemotherapy. Platinum AKT serine/threonine kinase 1 Homo sapiens