Pub. Date : 2014 Nov 14
PMID : 25278019
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway. | Calcium | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Rather, our studies indicate that orexin activates mTORC1 via extracellular calcium influx and the lysosome pathway involving v-ATPase and Rag GTPases. | Calcium | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | Moreover, a cytoplasmic calcium transient is sufficient to mimic orexin/GPCR signaling to mTORC1 activation in a v-ATPase-dependent manner. | Calcium | CREB regulated transcription coactivator 1 | Mus musculus |