Title : Mitochondrial dysfunction induced by a post-translationally modified amyloid linked to a familial mutation in an alternative model of neurodegeneration.

Pub. Date : 2014 Dec

PMID : 25261792






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Deposited ABri exhibits abundant post-translational pyroglutamate (pE) formation at the N-terminus, a feature seen in truncated forms of Abeta found in AD deposits, and co-exists with neurofibrillary tangles almost identical to those found in AD. Pyrrolidonecarboxylic Acid integral membrane protein 2B Homo sapiens
2 Deposited ABri exhibits abundant post-translational pyroglutamate (pE) formation at the N-terminus, a feature seen in truncated forms of Abeta found in AD deposits, and co-exists with neurofibrillary tangles almost identical to those found in AD. Pyrrolidonecarboxylic Acid integral membrane protein 2B Homo sapiens
3 The presence of pE conferred to the ABri molecule enhanced hydrophobicity and accelerated aggregation/fibrillization properties. Pyrrolidonecarboxylic Acid integral membrane protein 2B Homo sapiens