Title : Dipeptide prodrug approach to evade efflux pumps and CYP3A4 metabolism of lopinavir.

Pub. Date : 2014 Dec 10

PMID : 25261710






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Oral absorption of lopinavir (LPV) is limited due to P-glycoprotein (P-gp) and multidrug resistance-associated protein2 (MRP2) mediated efflux by intestinal epithelial cells. Lopinavir PGP Canis lupus familiaris
2 Oral absorption of lopinavir (LPV) is limited due to P-glycoprotein (P-gp) and multidrug resistance-associated protein2 (MRP2) mediated efflux by intestinal epithelial cells. Lopinavir PGP Canis lupus familiaris
3 Oral absorption of lopinavir (LPV) is limited due to P-glycoprotein (P-gp) and multidrug resistance-associated protein2 (MRP2) mediated efflux by intestinal epithelial cells. Lopinavir PGP Canis lupus familiaris
4 Oral absorption of lopinavir (LPV) is limited due to P-glycoprotein (P-gp) and multidrug resistance-associated protein2 (MRP2) mediated efflux by intestinal epithelial cells. Lopinavir PGP Canis lupus familiaris
5 In the present study, dipeptide prodrug approach was employed to circumvent efflux pumps (P-gp and MRP2) and CYP3A4 mediated metabolism of LPV. Lopinavir PGP Canis lupus familiaris