Title : Adduct levels from benzo[a]pyrenediol epoxide: Relative formation to histidine in serum albumin and to deoxyguanosine in DNA in vitro and in vivo in mice measured by LC/MS-MS methods.

Pub. Date : 2015 Jan 5

PMID : 25261590






1 Functional Relationships(s)
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1 An LC/MS-MS method to measure adducts from the benzo[a]pyrene (BP) metabolite (+-)-anti-BP-7,8-diol-9,10-epoxide ((+-)-anti-BPDE) to His(146) in serum albumin (SA), earlier evaluated on in vitro alkylated human SA, was tested for its applicability to mouse. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide albumin Homo sapiens