Pub. Date : 2014 Dec
PMID : 25261409
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Epigallocatechin-3-gallate sensitizes IFN-gamma-stimulated CD4+ T cells to apoptosis via alternative activation of STAT1. | epigallocatechin gallate | signal transducer and activator of transcription 1 | Homo sapiens |
| 2 | The increases in STAT1 activation and apoptosis induced by EGCG in IFN-gamma-activated CD4(+) T cells were almost completely abolished by a selective Src family kinase inhibitor, SU6656. | epigallocatechin gallate | signal transducer and activator of transcription 1 | Homo sapiens |
| 3 | In conclusion, the present study reports an alternative activation of STAT1 via Src by EGCG in IFN-gamma-activated CD4(+) T cells, which promotes the apoptosis of IFN-gamma-activated CD4(+) T cells and contributes to the improvement of T cell-mediated colitis. | epigallocatechin gallate | signal transducer and activator of transcription 1 | Homo sapiens |