Title : Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors.

Pub. Date : 2014 Sep 30

PMID : 25261369






1 Functional Relationships(s)
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Protein Name
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1 MLN0128 inhibited both mTORC1 and mTORC2 signaling, with more robust inhibition of downstream 4E-BP1 phosphorylation and cap-dependent translation compared to rapamycin in vitro. INK128 CREB regulated transcription coactivator 1 Mus musculus