Pub. Date : 2014 Nov 15
PMID : 25261240
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GPx2 suppression of H2O2 stress links the formation of differentiated tumor mass to metastatic capacity in colorectal cancer. | Hydrogen Peroxide | glutathione peroxidase 2 | Homo sapiens |
| 2 | Here, we studied how the H2O2-reducing enzyme glutathione peroxidase 2 (GPx2) regulates H2O2 stress and differentiation in patient-derived "colonosphere" cultures. | Hydrogen Peroxide | glutathione peroxidase 2 | Homo sapiens |
| 3 | Here, we studied how the H2O2-reducing enzyme glutathione peroxidase 2 (GPx2) regulates H2O2 stress and differentiation in patient-derived "colonosphere" cultures. | Hydrogen Peroxide | glutathione peroxidase 2 | Homo sapiens |
| 4 | Here, we studied how the H2O2-reducing enzyme glutathione peroxidase 2 (GPx2) regulates H2O2 stress and differentiation in patient-derived "colonosphere" cultures. | Hydrogen Peroxide | glutathione peroxidase 2 | Homo sapiens |
| 5 | Here, we studied how the H2O2-reducing enzyme glutathione peroxidase 2 (GPx2) regulates H2O2 stress and differentiation in patient-derived "colonosphere" cultures. | Hydrogen Peroxide | glutathione peroxidase 2 | Homo sapiens |
| 6 | GPx2 silencing caused accumulation of radical oxygen species, sensitization to H2O2-induced apoptosis, and strongly reduced clone- and metastasis-forming capacity. | Hydrogen Peroxide | glutathione peroxidase 2 | Homo sapiens |
| 7 | Finally, GPx2 expression was inversely correlated with H2O2-stress signatures in human colon tumor cohorts, but positively correlated with differentiation and proliferation. | Hydrogen Peroxide | glutathione peroxidase 2 | Homo sapiens |
| 8 | We conclude that H2O2 neutralization by GPx2 is essential for maintaining clonogenic and metastatic capacity, but also for the generation of differentiated proliferating tumor mass. | Hydrogen Peroxide | glutathione peroxidase 2 | Homo sapiens |