Pub. Date : 2014 Dec
PMID : 25256868
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Both GPER and membrane oestrogen receptor-alpha activation protect ventricular remodelling in 17beta oestradiol-treated ovariectomized infarcted rats. | Estradiol | G protein-coupled estrogen receptor 1 | Rattus norvegicus |
| 2 | The phosphorylation of Akt and eNOS was significantly decreased in infarcted rats and restored by oestradiol and G-1, implying the GPER pathway in this process. | Estradiol | G protein-coupled estrogen receptor 1 | Rattus norvegicus |
| 3 | Oestradiol-induced Akt phosphorylation was not abrogated by G-15 (a GPER blocker). | Estradiol | G protein-coupled estrogen receptor 1 | Rattus norvegicus |
| 4 | These data support the conclusions that oestradiol improves ventricular remodelling by both GPER- and membrane-bound ERalpha-dependent mechanisms that converge into the PI3K/Akt/eNOS pathway, unveiling a novel mechanism by which oestradiol regulates pathological cardiomyocyte growth after infarction. | Estradiol | G protein-coupled estrogen receptor 1 | Rattus norvegicus |