Title : Impact of genetic variability in CYP2D6, CYP3A5, and ABCB1 on serum concentrations of quetiapine and N-desalkylquetiapine in psychiatric patients.

Pub. Date : 2015 Apr

PMID : 25254417






5 Functional Relationships(s)
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1 Impact of genetic variability in CYP2D6, CYP3A5, and ABCB1 on serum concentrations of quetiapine and N-desalkylquetiapine in psychiatric patients. norquetiapine cytochrome P450 family 2 subfamily D member 6 Homo sapiens
2 BACKGROUND: To investigate the impact of genetic variability in CYP2D6, CYP3A5, and ABCB1 on steady-state serum concentrations of quetiapine and the active metabolite, N-desalkylquetiapine, in psychiatric patients. norquetiapine cytochrome P450 family 2 subfamily D member 6 Homo sapiens
3 In the multivariate analysis, mean C/D ratio of N-desalkylquetiapine was estimated to be 33% and 22% higher in inherent CYP2D6 poor metabolizers (P = 0.03) and heterozygous extensive metabolizers (P < 0.001), respectively, compared with inherent extensive metabolizers. norquetiapine cytochrome P450 family 2 subfamily D member 6 Homo sapiens
4 CONCLUSIONS: Genetic variability in CYP2D6 contributes to the interindividual variability in steady-state serum concentrations of N-desalkylquetiapine. norquetiapine cytochrome P450 family 2 subfamily D member 6 Homo sapiens
5 Although the metabolite exhibits relevant pharmacological activity, the quantitative effect of CYP2D6 genotype on serum concentration of N-desalkylquetiapine is probably of limited clinical relevance for quetiapine treatment. norquetiapine cytochrome P450 family 2 subfamily D member 6 Homo sapiens