Title : Analysis of an ECG record database reveals QT interval prolongation potential of famotidine in a large Korean population.

Pub. Date : 2015 Apr

PMID : 25253561






3 Functional Relationships(s)
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1 In vitro, the IC50 of famotidine for human-ether-a-go-go gene (hERG) channel inhibition was higher than 100 muM as determined by automated patch clamp hERG current assay, implying that hERG channel inhibition is not the underlying mechanism for QT prolongation. Famotidine ETS transcription factor ERG Homo sapiens
2 In vitro, the IC50 of famotidine for human-ether-a-go-go gene (hERG) channel inhibition was higher than 100 muM as determined by automated patch clamp hERG current assay, implying that hERG channel inhibition is not the underlying mechanism for QT prolongation. Famotidine ETS transcription factor ERG Homo sapiens
3 In vitro, the IC50 of famotidine for human-ether-a-go-go gene (hERG) channel inhibition was higher than 100 muM as determined by automated patch clamp hERG current assay, implying that hERG channel inhibition is not the underlying mechanism for QT prolongation. Famotidine ETS transcription factor ERG Homo sapiens