Title : Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol.

Pub. Date : 2015 Jan 1

PMID : 25247810






2 Functional Relationships(s)
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1 We also demonstrate that a proline residue in the meander region at position 427 in human CYP4B1 and 422 in rabbit CYP4B1 is important for protein stability and rescues the 4-IPO bioactivation of the human enzyme, but is not essential for the catalytic activity of the rabbit CYP4B1 protein. Proline cytochrome P450 4B1 Oryctolagus cuniculus
2 We also demonstrate that a proline residue in the meander region at position 427 in human CYP4B1 and 422 in rabbit CYP4B1 is important for protein stability and rescues the 4-IPO bioactivation of the human enzyme, but is not essential for the catalytic activity of the rabbit CYP4B1 protein. Proline cytochrome P450 4B1 Oryctolagus cuniculus