Title : Synthesis and preliminary mechanistic evaluation of 5-(p-tolyl)-1-(quinolin-2-yl)pyrazole-3-carboxylic acid amides with potent antiproliferative activity on human cancer cell lines.

Pub. Date : 2014 Nov 24

PMID : 25247770






1 Functional Relationships(s)
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1 Compound 4j with 2-chloro-4-pyridinyl group in the amide part exhibited promising cytotoxic activity against all cell lines with IC50 values of 1.6 muM, 3.3 muM and 1.1 muM for Huh7, MCF7 and HCT116 cells, respectively, and produced dramatic cell cycle arrest at SubG1/G1 phase as an indicator of apoptotic cell death induction. 2-chloro-4-pyridinyl MIR7-3 host gene Homo sapiens