Pub. Date : 2014 Oct 21
PMID : 25243829
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Measurement and characterization of superoxide generation from xanthine dehydrogenase: a redox-regulated pathway of radical generation in ischemic tissues. | Superoxides | xanthine dehydrogenase | Gallus gallus |
| 2 | It is also possible that XDH could generate significant quantities of superoxide, O2-, for cellular signaling or injury; however, this possibility and its potential ramifications have not been previously considered. | Superoxides | xanthine dehydrogenase | Gallus gallus |
| 3 | It is also possible that XDH could generate significant quantities of superoxide, O2-, for cellular signaling or injury; however, this possibility and its potential ramifications have not been previously considered. | Superoxides | xanthine dehydrogenase | Gallus gallus |
| 4 | To unambiguously determine if XDH can be a significant source of O2-, experiments were performed to measure and characterize O2- generation using XDH from chicken liver that is locked in the dehydrogenase conformation. | Superoxides | xanthine dehydrogenase | Gallus gallus |
| 5 | To unambiguously determine if XDH can be a significant source of O2-, experiments were performed to measure and characterize O2- generation using XDH from chicken liver that is locked in the dehydrogenase conformation. | Superoxides | xanthine dehydrogenase | Gallus gallus |
| 6 | Electron paramagnetic resonance spin trapping experiments with 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide demonstrated that XDH in the presence of xanthine produces significant amounts of O2-. | Superoxides | xanthine dehydrogenase | Gallus gallus |
| 7 | NAD+ and NADH inhibited the generation of O2- from XDH in a dose-dependent manner, with NAD+ exhibiting stronger inhibition than NADH at low physiological concentrations. | Superoxides | xanthine dehydrogenase | Gallus gallus |
| 8 | Decreased amounts of NAD+ and NADH, which occur during and following tissue ischemia, enhanced the generation of O2- from XDH in the presence of xanthine. | Superoxides | xanthine dehydrogenase | Gallus gallus |
| 9 | Thus, XDH can be an important redox-regulated source of O2- generation in ischemic tissue, and conversion to XO is not required to activate radical formation and subsequent tissue injury. | Superoxides | xanthine dehydrogenase | Gallus gallus |